It's a place that feels lively even when the casino isn't busy. The Seneca Niagara Resort looks and feels like the big casino hotel hotel it is, so guests can expect plenty of colors and patterns, bright lights, and noise. Nearby hotels even advertise their proximity to the casino or offer vouchers. side to have one, making the property a destination in its own right. It's also well-known because of its casino: This is the only hotel on the U.S. It towers above all else in the area, and takes up multiple blocks, so it's certainly not the type of place that's easy to miss. side of Niagara falls, both literally and figuratively. This massive 604-room resort and casino is one of the most notable hotels on the U.S.